Acetaminophen Depletes Glutathione Essential Formulas 05. Acetaminophen Toxicity Hospital Handbook Mechanism of acetaminophen induced hepatotoxicity. High dose of Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link